Effect of dermolipectomy on insulin sensitivity in obese women, with stable weight, after bariatric surgery / Efeito da dermolipectomia na sensibilidade à insulina em mulheres obesas, em fase de estabilidade de peso, após cirurgia bariátrica

AUTOR(ES)
DATA DE PUBLICAÇÃO

2009

RESUMO

Obesity induces insulin resistance, which is one of the steps to type 2 diabetes and cardiovascular diseases. In this scenario, the role of visceral adipose tissue is undoubted, but the same is not true for subcutaneous adipose tissue, especially in abdominal region. This confirms the importance of analysis of composition and distribution of adipose tissue in the whole body to define metabolic risk. If the role of adipose subcutaneous tissue is debatable, even more is the abdominal dermolipectomy impact on insulin sensitivity, measured by clamp. The aim of the present study was to evaluate the effect of abdominal dermolipectomy on insulin sensitivity and adipocytokines (adiponectin and leptin). We evaluated 17 female patients, age range 22-51 years, obese or overweight. All patients were ex-morbid obese and had performed Roux en Y gastric bypass surgery, at least one year before the baseline, with lost of at least 30% of their initial body weight, with stable weight (but still with huge amount of abdominal subcutaneous adipose tissue). From these, 12 concluded the study, performing the clamp at the beginning of the protocol and three months after the plastic surgery. Clamp lasted three hours, with glucose and insulin samples drawn each ten minutes. Regular insulin infusion dose was 1 mU/kg/min to raise and sustain insulinaemia. At baseline from each test, samples were draw for biochemistry, hormones and adipocytokines. Glucose uptake (M-value) was calculated in mg of glucose, per kg of body weight per minute, considering the last thirty minutes. HOMA-IR was also calculated. Before underwent the first clamp, patients performed DEXA (dual energy X-ray absorptiometry), all in the same equipment (Hologic), what enabled correlation of insulin sensitivity and fat free mass (FFM) in the first phase. Considering for statistical purposes the 12 patients, there was significant weight variation; from 84 kg to 81,8 kg (p=0,015) and also BMI variation from 31,1 x 30,3 kg/m2 (p=0,017). There was no FFM variation: 46,4 x 44,7 kg (p=0,119) neither glucose uptake (p=0,742). Even not of HOMA-IR (p=0,722) as expected, since there was not glucose uptake variation. In the first phase, insulin sensitivity was directly correlated with FFM (r=0,80; p=0,002) and inversely with age (r= - 0,71; p=0,10). There were no differences on adipocytokines: leptin (p=0,739) and adiponectin (p=0,940) before and after dermolipectomy. We conclude insulin sensitivity measured by clamp, was not modified by abdominal dermolipectomy in ex-morbid obese women, but still overwight or obese and metabolically healthy. Insulin sensitivity raises with FFM and lowers with age, after dermolipectomy, in this population.

ASSUNTO(S)

lipectomy resistência à insulina gordura subcutânea insulin resistance subcutaneous fat técnica clamp de glucose obesity lipectomia glucose clamp technique obesidade

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