Effect of Isoprinosine Against Challenge with A(H3N2)/Hong Kong Influenza Virus in Volunteers

AUTOR(ES)

Longley, Selden

RESUMO

Volunteers were challenged with A(H3N2)/Hong Kong/8/68 influenza virus while being given prophylaxis with either isoprinosine or placebo in a double-blind experiment. Isoprinosine, which had demonstrable antiviral activity in animal models, did not appear to protect humans from clinical influenza. The only beneficial effect of the drug observed was a slight, but significant, reduction in virus shedding.

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