Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters
AUTOR(ES)
Lopez, Talita Christine Camilo, Martins, Manoela Domingues, Pavesi, Vanessa Christina Santos, Ferreira, Leila Soares, Bussadori, Sandra Kalil, Moreira, Maria Stella, Marques, Marcia Martins
FONTE
Braz. oral res.
DATA DE PUBLICAÇÃO
11/06/2013
RESUMO
The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D-5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D-5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum-phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm2, 40 mW, 1.11 W/cm2, 6.6 J/cm2, power density applied daily of 39.6 J/cm2, in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey's test (p ≤0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy).
Documentos Relacionados
- Laser phototherapy as a treatment for radiotherapy-induced oral mucositis
- Use of therapeutic laser for prevention and treatment of oral mucositis
- Effect of Topical 2% Eucalyptus Extract on 5-FU-Induced Oral Mucositis in Male Golden Hamsters
- Estudo do efeito da atorvastatina na mucosites oral induzida por 5-fluorouracil em hamsters.
- Efeitos do imiquimode e do laser em baixa intensidade (λ660nm) no câncer quimicamente induzido em mucosa oral de hamsters).