Effect of SpeB and EndoS from Streptococcus pyogenes on Human Immunoglobulins

AUTOR(ES)

Collin, Mattias

FONTE

American Society for Microbiology

RESUMO

Streptococcus pyogenes secretes a specific immunoglobulin G (IgG)-protease, SpeB, as well as the IgG glycan-hydrolyzing enzyme EndoS. Here we show that SpeB also degrades IgA, IgM, IgD, and IgE. We also show that EndoS only hydrolyzes the glycan moiety on native but not denatured IgG. Thus, SpeB has a broad immunoglobulin-degrading activity, while EndoS is highly specific for IgG.

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