Effect of Thymine Starvation on Messenger Ribonucleic Acid Synthesis in Escherichia coli
AUTOR(ES)
Luzzati, Denise
RESUMO
Luzzati, Denise (Institut de Biologie Physico-Chimique, Paris, France). Effect of thymine starvation on messenger ribonucleic acid synthesis in Escherichia coli. J. Bacteriol. 92:1435–1446. 1966.—During the course of thymine starvation, the rate of synthesis of messenger ribonucleic acid (mRNA, the rapidly labeled fraction of the RNA which decays in the presence of dinitrophenol or which hybridizes with deoxyribonucleic acid) decreases exponentially, in parallel with the viability of the thymine-starved bacteria. The ability of cell-free extracts of starved bacteria to incorporate ribonucleoside triphosphates into RNA was determined; it was found to be inferior to that of extracts from control cells. The analysis of the properties of cell-free extracts of starved cells shows that their decreased RNA polymerase activity is the consequence of a modification of their deoxyribonucleic acid, the ability of which to serve as a template for RNA polymerase decreases during starvation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=276442Documentos Relacionados
- Effect of Thymine Starvation on Deoxyribonucleic Acid Repair Systems of Escherichia coli K-12
- Inhibition of Messenger Ribonucleic Acid Synthesis in Escherichia coli by Thiolutin
- Loss of Deoxyribonucleic Acid-Thymine During Thymine Starvation of Escherichia coli
- Influence of Thymine Starvation on the Integrity of Deoxyribonucleic Acid in Escherichia coli
- Amino Acid Regulation of Messenger Ribonucleic Acid Synthesis in T4-infected Escherichia coli