Effective and Long-Lasting Immunity against the Parasite Leishmania major in CD8-Deficient Mice
AUTOR(ES)
Huber, Magdalena
FONTE
American Society for Microbiology
RESUMO
The results of earlier investigations that tested whether CD8+ T cells are required in the defense against Leishmania major have been inconsistent. We used CD8-deficient mice to directly address this issue. After primary infection with L. major, CD8-deficient mice controlled the infection for over 1 year and mounted strong T helper 1 cell responses. Thus, CD8+ T cells are not required for the long-term control of a primary infection with L. major.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=108466Documentos Relacionados
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