Effects of Fluconazole and Clarithromycin on Rifabutin and 25-O-Desacetylrifabutin Pharmacokinetics
AUTOR(ES)
Jordan, M. Kelli
FONTE
American Society for Microbiology
RESUMO
Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together with rifabutin. Patients should be monitored for adverse effects of rifabutin administered concomitantly with clarithromycin and/or fluconazole.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90031Documentos Relacionados
- Effects of clarithromycin and rifabutin alone and in combination on intracellular and extracellular replication of Mycobacterium avium.
- Pharmacokinetics of rifabutin.
- Effect of Grapefruit Juice on Clarithromycin Pharmacokinetics
- Bronchopulmonary Pharmacokinetics of Clarithromycin and Azithromycin
- Intrapulmonary pharmacokinetics of clarithromycin and of erythromycin.
