Effects of H2O2, Fe2+ and Fe3+ on curcumin-induced chromosomal aberrations in CHO cells

AUTOR(ES)

Antunes, Lusânia Maria Greggi, Araújo, Maria Cristina Paiva, Dias, Francisca da Luz, Takahashi, Catarina Satie

FONTE

Genetics and Molecular Biology

DATA DE PUBLICAÇÃO

2005-03

RESUMO

The effects of H2O2, Fe2+ and Fe3+ on curcumin-induced clastogenicity were evaluated in CHO cells. Curcumin combined with H2O2 did not increase the chromosomal aberrations more than expected based on a simple additive effect. In contrast, the combination of curcumin-Fe significantly decreased the total number of chromosomal aberrations and the number of abnormal metaphases. The clastogenicity of curcumin may be related to its pro-oxidant properties and its ability to generate free radicals.

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