Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats
AUTOR(ES)
Brito, Marcus Vinicius Henriques, Yasojima, Edson Yuzur, Percário, Sandro, Ribeiro Júnior, Rubens Fernando Gonçalves, Cavalcante, Lainy Carollyne da Costa, Monteiro, Andrew Moraes, Couteiro, Rodrigo Paracampo, Rodrigues, Ivone Aline da Silva, Santos, Hellen Aparecida Geyer dos
FONTE
Acta Cir. Bras.
DATA DE PUBLICAÇÃO
2017-03
RESUMO
Abstract Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion.
Documentos Relacionados
- Perconditioning associated to hypertonic saline solution on liver function improvement after ischemia/reperfusion injury
- Olmesartan restores the protective effect of remote ischemic perconditioning against myocardial ischemia/reperfusion injury in spontaneously hypertensive rats
- Pentoxifylline associated to hypertonic saline solution attenuates inflammatory process and apoptosis after intestinal ischemia/reperfusion in rats
- Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
- Effects of remote ischemic preconditioning and topical hypothermia in renal ischemia-reperfusion injury in rats