Effects of the exposure to cigarette smoke and residual oil fly ash (ROFA) in lungs of C57/Bl6 mice / Efeito da exposição à fumaça de cigarro e ao resíduo de óleo diesel (ROFA) em pulmões de camundongos C57/BI6
AUTOR(ES)
Paolo José Cesare Biselli
DATA DE PUBLICAÇÃO
2008
RESUMO
Many of the mechanisms leading to CPOD (Chronic Pulmonary Obstructive Disease) are not completely understood. In the present study, we exposed C57/Bl6 mice, for two months, to cigarette smoke and/or ROFA (Residual Oil Fly Ash). Animals exposed to cigarette smoke had an increased in proximal airways resistance, probably due to the thickening of airways walls that followed changes in epithelial cells. These animals also had a small degree of emphysema, once air spaces enlargement could be noticed in circumscribed lung areas. We observed no inflammatory cells recruitment, elastic or collagen fibers deposition or increases in oxidative stress, measured by staining Isoprotane8. This study shows an early stage of the CPOD development, in which we can detect changes in epithelial cells and a small degree of emphysema, which could be mediated by these same epithelial cells
ASSUNTO(S)
tobacco environmental pollution chronic obstructive/physiopathology doença pulmonar obstrutiva crônica/fisiopatologia mice pulmonary emphysema tabaco pulmonary disease camundongos poluição ambiental enfisema pulmonar
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