Efficacies of Zinc-Finger-Active Drugs against Giardia lamblia
AUTOR(ES)
Nash, Theodore
FONTE
American Society for Microbiology
RESUMO
Twenty-nine of 34 (85%) Zn-finger-active compounds at 300 μM or less inhibited the growth of Giardia lamblia. The most active compound, disulfiram (Antabuse), was cidal at 1.23 ± 0.32 μM. In the adult mouse model, significant in vivo activity was demonstrated by increased cure rates and decreased parasite burdens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=105627Documentos Relacionados
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