Efficient immunity against Leishmania major in the absence of interleukin-6.
AUTOR(ES)
Moskowitz, N H
RESUMO
Mice genetically deficient in the pleiotropic cytokine interleukin-6 (IL-6) exhibit immunodeficiency against viral, bacterial, and fungal pathogens. When challenged with the protozoan parasite Leishmania major, IL-6-deficient mice controlled infection and mounted strong Th1 responses as efficiently as IL-6-sufficient littermates. Thus, the successful activation of parasitized macrophages and class II-restricted T cells does not require a full inflammatory repertoire.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=175340Documentos Relacionados
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