Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.

AUTOR(ES)

Normanly, J

RESUMO

Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.

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