Elevated mutation rate in mutT bacteria during starvation: evidence for DNA turnover?
AUTOR(ES)
Bridges, B A
RESUMO
The rate of appearance of prototrophic revertants when Escherichia coli tyrA14 (ochre) or trpA23 bacteria were incubated on plates lacking the required amino acid was greatly elevated when the organisms also carried a mutT mutation. One possible explanation for this result is that the amount of DNA replication or turnover under these conditions is much greater than has been previously recognized.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=177999Documentos Relacionados
- Bacteriophage Mu-1-induced mutation to mutT in Escherichia coli.
- DNA Synthesis and Viability of a mutT Derivative of Escherichia coli WP2 under Conditions of Amino Acid Starvation and Relation to Stationary-Phase (Adaptive) Mutation
- A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication.
- Activity of the Escherichia coli mutT mutator allele in an anaerobic environment.
- Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein