Enhancer sequences responsible for DNase I hypersensitivity in polyomavirus chromatin.
AUTOR(ES)
Bryan, P N
RESUMO
DNase I preferentially cleaves polyomavirus minichromosomes at two sites in the enhancer, each of which comprises the sequence AAGCAPuPuAAG flanked by short inverted repeats. A tandem duplication of this sequence generates an additional hypersensitive locus. Mutations which alter either the AAGCAPuPuAAG or flanking repeats diminish hypersensitivity. This region must determine the chromatin conformation recognized by DNase I.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=367766Documentos Relacionados
- Isolation of a subclass of nuclear proteins responsible for conferring a DNase I-sensitive structure on globin chromatin.
- Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin.
- Transcription-induced nucleosome 'splitting': an underlying structure for DNase I sensitive chromatin.
- High-resolution mapping of S1- and DNase I-hypersensitive sites in chromatin.
- DNA methylation: correlation with DNase I sensitivity of chicken ovalbumin and conalbumin chromatin.