Entrance and survival of Salmonella typhimurium and Yersinia enterocolitica within human B- and T-cell lines.

AUTOR(ES)

Verjans, G M

RESUMO

Lymphocytes, located within the Peyer's patches, might be involved in the dissemination of enteropathogenic Salmonella typhimurium and Yersinia enterocolitica bacteria. To test this hypothesis, we have investigated the susceptibility of human B- and T-cell lines to bacterial adhesion and invasion. The two S. typhimurium strains analyzed were highly invasive, while the two Y. enterocolitica (O:8) strains adhered to the B- and T-cell lines but did not enter the cell lines in significant amounts. We hypothesize that the incapability of the Y. enterocolitica (O:8) strains to enter the human B- and T-cell lines is most probably due to the bacterial inability to induce the internalization process upon adhesion to both cell lines. Although immortalized B- and T-cell lines were used in this study, the results presented suggest the possibility that both cell types could play a role in the dissemination of intracellularly residing S. typhimurium in vivo.

Documentos Relacionados

• Evidence for different interleukin 1 receptors in murine B- and T-cell lines.
• Adoptive transfer of murine host protection to salmonellosis with T-cell growth factor-dependent, Salmonella-specific T-cell lines.
• Development and characterization of allospecific long-term human cytolytic T-cell lines.
• Distinct Factors Regulate the Murine RAG-2 Promoter in B- and T-Cell Lines
• Identification of Chlamydia trachomatis antigens by use of murine T-cell lines.