Envolvimento dos receptores 5-HT2c do hipocampo ventral na modulação de estados de ansiedade em ratos

AUTOR(ES)

Marília Greidinger Carvalho

DATA DE PUBLICAÇÃO

2010

RESUMO

The present study investigated the effects of pharmacological blockade of 5-HT2C receptors of the ventral hippocampus (VH) on anxiety levels of rats induced by 5-HT2C agonists. Ten minutes after intraperitoneal (i.p.) injections of either saline (0.9%) or the 5-HT2C agonist WAY-161503 (3mg/kg), rats were bilaterally microinjected in the VH with saline or with the selective 5-HT2C antagonist SB-242084 at doses of 0.1, 0.5 or 1.5 μg/0.2 μl. Five minutes after the microinjections, each animal was exposed for five minutes to the Elevated Plus-Maze (EPM). The following behavioral categories were recorded as anxiety indexes: percentages of open arm entries and of time on open- arms, time spent on risk-assessment and scanning, as well as the number of visits to the extremity of the open-arms. The absolute number of closed arm entries was used locomotor activity index. Results indicated anxiogenic effects on animals peripherically pre-treated with the agonist WAY-161503 and microinjected with saline in the VH. Microinjection of the 5-HT2C antagonist SB-242084 in the VH blocked the anxiogenic effects induced by i.p. WAY-161503 injections. These outcomes point toward participation of 5-HT2C receptors in the VH in the modulation of anxiety states in rats exposed to EPM.

ASSUNTO(S)

ansiedade hipocampo ventral receptores 5-ht2c serotonina psicologia anxiety ventral hippocampus 5-ht2c receptors serotonin

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