Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect.

AUTOR(ES)

den Hollander, J G

RESUMO

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

Documentos Relacionados

• Different patterns of bacterial DNA synthesis during postantibiotic effect.
• Impact of pH and cationic supplementation on in vitro postantibiotic effect.
• Fertilization in Drosophila. II. Time of inactivation of a gene effect.
• Novel method for assessing postantibiotic effect by using the Coulter counter.
• An automated enzymatic method for measurement of D-arabinitol, a metabolite of pathogenic Candida species.