Epidemiological characterization of resistance and PCR typing of shigella flexneri and shigella sonnei strains isolated from bacillary dysentery cases in Southeast Brazil / Caracterização biologica e molecular de amostras de shigella flexneri e shigella sonnei isoladas da regiao de Campinas-SP

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Shigella spp are gram-negative, anaerobic facultative, non-motile, and non-sporulated bacilli of the Enterobacteriaceae family, responsible for Shigellosis or the Bacillary Dysentery (BD) disease, an important cause of worldwide morbidity and mortality. The pathogenic determinants of Shigella spp include high molecular weight plasmids responsible for the bacterial invasive capacity, as well as chromosomal genes encoding for different pathogenic, factors such as exotoxins that destroy epithelial host cells. Little is known about the antibiotic resistance profiles and the population structure of Shigella species isolated from humans in Brazil. In this work, we have studied the antibiotic resistance profiles and the clonal structure of Shigella strains isolated from humans in different cities located in the region of Campinas, a city in the state of São Paulo, Brazil. We have also related the antibiotic resistance of these strains with the bacterial clonal groups determined by the molecular techniques ERIC, REP, and DRE-PCR. Our data indicate that many strains of S. flexneri and S. sonnei are multiresistant, and our results also support the circulation of specific clones among the cities. These data indicate that the human sanitary conditions in the cities analyzed herein should be improved

ASSUNTO(S)

reação em cadeira de polimerase patogenicidade drogas - resistencia em microorganismos patogenicity drug resistance shigella shigella polymerase chain reaction

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