Epithelial stem cells in the mammary gland: casting light into dark corners
AUTOR(ES)
Anderson, Elizabeth
FONTE
BioMed Central
RESUMO
The epithelial structures of the human breast or the mouse mammary gland are derived from a relatively small number of multipotent, tissue-specific stem cells, of which we are surprisingly ignorant. We do not know how many are required to produce a complete mammary gland, how many times they divide during the process, where they are situated in the gland, or even what they look like. We want to know the answers to these questions, not just to satisfy intellectual curiosity, but also because the answers may shed light on the evolution of breast cancer. Now, studies carried out by Kordon and Smith at the National Cancer Institute have pointed the way toward a new understanding of mammary stem cells and their progeny.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=138503Documentos Relacionados
- Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
- Postnatal evolution of the rat pineal gland: light microscopy.
- Neoplastic transformation of epithelial cells in whole mammary gland in vitro.
- microRNAs and the mammary gland: a new understanding of gene expression
- First description of basaloid carcinoma of the canine mammary gland: case report