Epstein-Barr Virus Regulates STAT1 through Latent Membrane Protein 1

AUTOR(ES)

Richardson, Ciarán

FONTE

American Society for Microbiology

RESUMO

This study shows a mechanism for the increase of signal transducer and activator of transcription 1 (STAT1) in Epstein-Barr virus-immortalized cells. Latent membrane protein 1 (LMP-1) expression was sufficient to induce STAT1 expression, DNA binding, and transcriptional activity. LMP-1-expressing cells can induce an increase in STAT1 expression in LMP-negative cells in the same culture, suggesting an indirect regulation of STAT1 expression. The increase in STAT1 expression is mediated by the C-terminal activating region 1 (CTAR-1) and/or CTAR-2 domains of LMP-1 and is inhibited by mutant IκB, demonstrating a role for NFκB in LMP-1-mediated STAT1 expression.

Documentos Relacionados

• Epstein-Barr Virus Latent Membrane Protein 2A Regulates c-Jun Protein through Extracellular Signal-Regulated Kinase
• The Epstein-Barr Virus SM Protein Induces STAT1 and Interferon-Stimulated Gene Expression
• Epstein-Barr virus nuclear antigen 2 transactivates latent membrane protein LMP1.
• Interferon Regulatory Factor 7 Regulates Expression of Epstein-Barr Virus Latent Membrane Protein 1: a Regulatory Circuit
• Epstein–Barr virus latent membrane protein 1 activation of NF-κB through IRAK1 and TRAF6