Establishment and maintenance of sister chromatid cohesion in fission yeast by a unique mechanism
AUTOR(ES)
Tanaka, Koichi
FONTE
Oxford University Press
RESUMO
During S phase, chromatid cohesion is established only between nascent sisters and with faithful pairing along their entire region, but how this is ensured is unknown. Here we report that sister chromatid cohesion is formed and maintained by a unique mechanism. In fission yeast, Eso1p, functioning in close coupling to DNA replication, establishes sister chromatid cohesion whereas the newly identified Cohesin-associated protein Pds5p hinders the establishment of cohesion until counteracted by Eso1p, yet stabilizes cohesion once it is established. Eso1p interacts physically with Pds5p via its Ctf7p/Eco1p-homologous domain.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=125673Documentos Relacionados
- Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair
- Fission Yeast Eso1p Is Required for Establishing Sister Chromatid Cohesion during S Phase
- Mutational Analysis of the Drosophila Sister-Chromatid Cohesion Protein Ord and Its Role in the Maintenance of Centromeric Cohesion
- Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein
- Rec8p, a Meiotic Recombination and Sister Chromatid Cohesion Phosphoprotein of the Rad21p Family Conserved from Fission Yeast to Humans