Estudo dos efeitos do laser infra-vermelho (810nm) no modelo de inflamação aguda induzida em joelho de ratos. / Study of the effects of near-red laser (810nm) on acute inflammation of the knee in rats.
AUTOR(ES)
Rodney Capp Pallotta
DATA DE PUBLICAÇÃO
2009
RESUMO
Introduction. Arthritis of the knee (AK) is the most common type of osteoarthritis, and its prevalence is rising in parallel with the increasing age of the population.. Here we investigate the effects of Low Level Laser Therapy (infra-red, 810 nm) in experimentally induced rat knee osteoarthritis. Methods. Male wistar rats (150 200g) were anaesthetized with halothane 1% prior the injection of pro-inflammatory compounds. Carrageenan and Kaolin (both 3%) administered intra-articular. After 6 hours all animals were killed by decaptation and articular cavity was washed and collected. Articular Tissue was carefully removed for edema and Real-time PCR analysis in order to evaluate COX-1 and COX-2 expression. Total and differential cell account, mieloperoxidase activity, IL-b, TNF-a, IL-6 was also analysed. Results. Low Level laser therapy was able to significantly inhibit the total number of leukocytes as well as the mieloperoxidase activity, polymorphonuclear cells at the inflammatory site, vascular extravasation, IL-1, TNF-alpha, IL-6 and prostaglandin E2. Conclusions. Low Level Laser Therapy operating in 810 nm markedly reduced inflammation in carrageenan, kaolin-induced knee osteoarthritis.
ASSUNTO(S)
low level laser therapy (lllt) arthritis inflamação inflammation laser de baixa potência (lbp) rats ratos osteoartrite osteoarthritis artrite
Documentos Relacionados
- Estudo da fototerapia de baixa potência no modelo de inflamação aguda induzida no joelho de ratos.
- Efeito do laser de baixa potência (810 nM) na tendinite induzida por colagenase em tendão calcâneo de ratos.
- EFEITO DO LASER, λ904 nm, NA CICATRIZAÇÃO POR 1 INTENÇÃO NO MODELO EXPERIMENTAL EM RATOS.
- Crotoxina: uma nova abordagem na inflamação alérgica pulmonar em ratos.
- Construção e caracterização de um detetor de metal-isolante-metal para lasers no infra-vermelho longinquo