Estudo eletroquimico das caracteristicas trombogenicas de hidrogeis polimericos

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

Polymeric hydrogels to be used as hemo-compatible biomaterials, have been studied in relation to their biological, mechanical, physico-chemical and morphological properties, among others, but as far as is known no studies have treated their hemo-compatible characteristics from an electro-chemical perspective. In this work, previously oxidized low density polyethylene film surfaces were covered with blends of PV A and PVP, two well studied hydrogels, and solutions of human and bovine serum albumin. The hemo-compatibility of the blends were evaluated through Platelet Adhesion Tests in human blood and monitored by Scanning Electron Microscopy. Contact angle measurements were performed to evaluate the hydrophilic behavior of the polymeric surfaces. The samples covered with hydrogels and albumin were analyzed by Electrochemical Impedance Spectroscopy, with the object of evaluating this technique for the examination of the thrombogenicity of polymers. Virgin and oxidized PE films were also characterized with the aim of verifying a possible contribution of the oxidation process in the electrochemical behavior of the film matrices. The results indicate a great sensitivity of the technique in the detection of variations resulting from the process of oxidation of the film matrices, without, however, having been possible to establish a standard relation. The electrochemical analysis of the covered films revealed a decrease in the modulus of the impedance together with an improvement in the anti-thrombogenic and hydrophilic characteristics of these films. The films electrochemical behavior were evaluated by the equivalent circuit s theory and the analogous circuit for the polymer/solution systems was stablished

ASSUNTO(S)

eletroquimica espectroscopia de impedancia polimeros soluveis em agua

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