Estudo imunohistoquimico e analise univariada dos fatores prognosticos de tumores de glandula submandibular

AUTOR(ES)
DATA DE PUBLICAÇÃO

2002

RESUMO

The aim of this work was to analyze c1inocopathological and immunohistochemical expression in submandibular salivary gland tumors. A total of 112 tumors was evaluated, being 61 benign and 51 malignant. The benign tumors were compose of 60 pleomorphic adenomas and 1 basal cell adenoma. Among the malignancies, 23 were adenoid cystic carcinoma, 16 mucoepidermoid carcinomas, 4squamous cell carcinomas, 4adenocarcinomas NOS, 1 basal cell adenocarcinoma, 1 salivary duct carcinoma, 1 malignant myoepithelioma and 1 undifferentiated carcinoma. The patients with benign tumors presented a mean age of 36.3 years and 61.7% of them were females. Microscopically, most of the pleomorphic adenomas were rich in myxocondroid areas (subtype II) and all cases were negatives for p53 and Ki-67. Considering malignant tumors, the mean age was 55.4 years and 64.7% of the patients were males. At the time of diagnosis, 64.7% of the patients presented tumors in advanced c1inical stage, 15.7% presented regional lymph nodes metastases and 7.84% distant metastases. The expression of PCNA, Ki-67, c-erbB-2, CEA e bc1-2 was not correlated with c1inicopathological features (p<0.05). However, p53 expression was associated with T and N stages, death and overall survival (p<0.05). Our results showed that pleomorphic adenomas of submandibular glands presented low growth rate and good prognosis. Adenoid cystic carcinoma was the most common malignant tumor, and submandibular malignant tumors presented poor prognosis, mainly in tumors with advanced c1inical stage and with p53 expression

ASSUNTO(S)

glandulas salivares imunohistoquimica

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