Estudo prospectivo para verificar a ocorrencia e distribuição anatomica de nevos melanociticos numa comunidade holandesa no Brasil : seguimento de 5 anos / Prospective study to verify the ocurrence and anatomic distribution of melanocytic nevi in a dutch community in Brazil : 5-year follw-up

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

The objective of this study was to verify the development of melanocytic nevi (MN) and ephelides, important risk factors for cutaneous melanoma, in students of a private school who were mostly Dutch and Dutch descendants in Holambra, Brazil and to obtain information about the effects of environmental factors on these individuals who maintained phenotypical characteristics similar to those of their ancestors. In 1999, the author began a cohort study to count NM in 282 students (53.9% boys) aged between 3 and 17 years. Five years later, the study follow-up was carried out by the same author involving 148 (52.43% response) students, 73 (49.32%) boys and 75 (50.67%) girls aged between 8 and 22 years, from 2006 to 2007. The social-demographic and physical characteristics, as well as the cutaneous manifestations were verified. Cutaneous manifestations alterations and the relationship of these main variables (age, sex, skin phototype, eye color, hair color, photoprotection mechanisms and ethnic group) with the presence of MN and ephelides at the beginning and at the end of study were verified. The increase in number of MN, both in covered areas and exposed areas was significant at the end of study. The study also revealed that the boys had a higher total number of MN, both in covered areas and exposed areas, than the girls and there was significant increase of dysplastic nevi (DN) at the end of study. The increase of occurrence of ephelides in students from the non-mixed group, with skin phototype I, with light-colored hair and eyes and in those who never used protection was significant. The result of probability analysis with a 5 % significance level and 95% confidence interval for the odds ratio revealed that the boys have greater probability of developing nevi in covered and exposed areas than the girls, and that the non-mixed and mixed ethnic groups with light-colored hair had respectively greater probability of developing MN than the students from other ethnic groups and those with dark-colored hair. The analysis also revealed that the students with skin phototype I had greater probability of developing MN in the covered areas than the students with skin phototype II and III. The occurrence of ephelides was greater in the students with skin phototype I, with paternal and maternal Dutch ascendants and with light-colored hair. This study may be considered the first prospective study carried out in Brazil to verify the development of MN. The data obtained in this study contributed to demonstrate that the students that retain the phenotypical characteristics of their ancestors have greater probability of developing MN and ephelides than the other ethnic groups

ASSUNTO(S)

dutch in brazil nevo pigmentado - etiologia fatores de risco radiação solar pigmented solar radiation holandeses - brasil nevus ethnic groups grupos etnicos

ACESSO AO ARTIGO

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