Evaluation of the influence of base and alkyl bromide on synthesis of pyrazinoic acid esters through fatorial design
AUTOR(ES)
Fernandes, João Paulo dos Santos, Felli, Veni Maria Andres
FONTE
Química Nova
DATA DE PUBLICAÇÃO
2009
RESUMO
Pyrazinoic acid esters have been synthesized as prodrugs of pyrazinoic acid. In the literature, its preparation is reported through the reaction of pyrazinoyl chloride with alcohols and the reaction with DCC/DMAP. In this work, it is reported a 2² factorial design to evaluate the preparation of these esters through the substitution of alkyl bromides with carboxylate anion. The controlled factors were alkyl chain length of bromides (ethyl and hexyl) and the used base (triethylamine and DBU). Results revealed that the used base used has significant effect on yield, and alkyl bromide used has neither significant influence, nor its interaction effect with base.
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