Evidence that a major class of mouse endogenous long terminal repeats (LTRs) resulted from recombination between exogenous retroviral LTRs and similar LTR-like elements (LTR-IS).
AUTOR(ES)
Schmidt, M
RESUMO
Two endogenous retroviral long terminal repeats (LTRs) were sequenced and compared to LTR-IS (a family of insertion-element-like sequences with structural features of solitary retroviral LTRs) and to Moloney murine leukemia virus DNA. The sequence comparisons revealed that the major difference between these two endogenous LTRs is a 190-base-pair segment which is also present in LTR-IS elements. Hybridization analysis of DNAs from several mouse species using specific probes shows linkage of the 190-base-pair segment to a LTR-IS specific fragment. It is concluded that the major class of endogenous LTRs has been generated by recombination between exogenous retroviral LTRs and LTR-IS sequences.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=391997Documentos Relacionados
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