Evidence That an Acute Increase in Glomerular Filtration Has Little Effect on Sodium Excretion in the Dog unless Extracellular Volume is Expanded*

AUTOR(ES)

Lindheimer, Marshall D.

RESUMO

The concept that acute increases in glomerular filtration rate (GFR) will cause large concomitant increases in sodium excretion has been re-examined. In previous work, GFR was elevated by volume expansion, usually with saline infusions. Recent evidence shows that tubular reabsorption is depressed during saline loading; hence, the independent effect of increased GFR on sodium excretion cannot be assessed.

Documentos Relacionados

• THE EFFECT OF VARIATIONS IN SOLUTE EXCRETION AND GLOMERULAR FILTRATION ON WATER DIURESIS 1
• The control of glomerular filtration rate and renal blood flow in chronically volume-expanded rats.
• Influence of Expansion of Extracellular Volume on Tubular Reabsorption of Sodium Independent of Changes in Glomerular Filtration Rate and Aldosterone Activity *
• THE EFFECT OF CHANGES IN BODY SODIUM ON EXTRACELLULAR FLUID VOLUME AND ALDOSTERONE AND SODIUM EXCRETION BY NORMAL AND EDEMATOUS MEN 1
• Effects of hematocrit on renal hemodynamics and sodium excretion in hydropenic and volume-expanded dogs