Exon/intron organization and complete nucleotide sequence of an HLA gene.
AUTOR(ES)
Malissen, M
RESUMO
We have isolated and determined the sequence of a genomic clone containing the gene for a human class I transplantation antigen. The gene contains seven exons. The first five exons code respectively for a signal peptide, for the first, second, and third extracellular domains of the protein molecule, and for the transmembrane region. The cytoplasmic segment is encoded by part of the fifth and the sixth and the seventh exons. The structure of the protein encoded by this unit is closely homologous with known class I transplantation antigens.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=345859Documentos Relacionados
- Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene.
- ExInt: an Exon/Intron database
- Complete nucleotide sequence and exon-intron boundaries of the 5' non-coding region of the mouse N-myc gene.
- Exon/intron organization of the chicken type II procollagen gene: intron size distribution suggests a minimal intron size.
- Complete Nucleotide Sequence of the Mouse Lactate Dehydrogenase-a Functional Gene: Comparison of the Exon-Intron Organization of Dehydrogenase Genes