Expression in Organ Culture of Agouti Locus Genes of the Mouse
AUTOR(ES)
Knisely, A. S.
RESUMO
Cleffmann (1963) reported that pigment cells of the lethal yellow (Ay/a) genotype change to black immediately upon cultivation, and continue to produce black pigment unless sulfhydryl reagents are added to the culture medium. We have attempted to repeat this observation and have not been able to do so. We also have been unable to induce the synthesis of yellow pigment by adding glutathione to cultures of agouti (A/A) skin. We therefore suggest that hypotheses which attempt to explain the action of agouti locus genes on the basis of effects of sulfhydryl compounds be considered with caution.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1213287Documentos Relacionados
- Expression of Genes at the Agouti Locus and Mitotic Activity of the Hair Bulb of the Mouse
- Molecular Markers for the agouti Coat Color Locus of the Mouse
- Influence of Maternal Phenotype on Metabolic Differentiation of Agouti Locus Mutants in the Mouse
- Molecular Genetic Characterization of Six Recessive Viable Alleles of the Mouse Agouti Locus
- Molecular characterization of a region of DNA associated with mutations at the agouti locus in the mouse.
