Expression of Human MxA Protein in Mosquito Cells Interferes with LaCrosse Virus Replication

AUTOR(ES)

Miura, Tanya A.

FONTE

American Society for Microbiology

RESUMO

Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection.

Documentos Relacionados

• Antivirally active MxA protein sequesters La Crosse virus nucleocapsid protein into perinuclear complexes
• Analysis of LaCrosse virus S mRNA 5' termini in infected mosquito cells and Aedes triseriatus mosquitoes.
• Human MxA Protein Protects Mice Lacking a Functional Alpha/Beta Interferon System against La Crosse Virus and Other Lethal Viral Infections
• Human MxA Protein Inhibits the Replication of Crimean-Congo Hemorrhagic Fever Virus
• Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein.