Facilitation of Development of Resistance to Morphine Analgesia by Desglycinamide9-Lysine Vasopressin

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RESUMO

Desglycinamide9-lysine vasopressin facilitates development of resistance to the analgesic action of morphine in mice if morphine is administered before the peptide. Desglycinamide9-lysine vasopressin is not a morphine antagonist, and does not appear to cause either hyperalgesia or alteration of the response to the technique used for evaluating analgesia.

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