FACTORS INFLUENCING PREMATURE INDUCTION OF UDP-GLUCURONYLTRANSFERASE ACTIVITY IN CULTURED CHICK EMBRYO LIVER CELLS

AUTOR(ES)

Skea, Brian R.

RESUMO

Very young (5-day-old) chick embryo livers during organ culture on rafts over a chemically defined nutrient medium precociously develop, from zero, adult levels of UDP-glucuronyltransferase activity. Induction of enzyme does not require DNA synthesis or mitosis, or exposure to hormones, serum, or tissue extracts. Thus, this functional differentiation of embryo liver is apparently not dependent on cell proliferation or on extrinsic substances other than simple nutrients.

Documentos Relacionados

• Defective function of a microsomal UDP-glucuronyltransferase in Gunn rats.
• The full length coding sequence of rat liver androsterone UDP-glucuronyltransferase cDNA and comparison with other members of this gene family.
• Induction of δ-Aminolevulinic Acid Synthetase in Chick Embryo Liver Cells in Culture
• Specific factors influencing histotypic aggregation of chick embryo hepatocytes.
• Mechanisms of transmembrane calcium movement in cultured chick embryo ventricular cells