Failure of heavy chain glycosylation of IgG in some patients with common, variable agammaglobulinemia.
AUTOR(ES)
Ciccimarra, F
RESUMO
Four patients with common, variable agammaglobulinemia were preveiously reported to have normal numbers of circulating B lymphocytes which synthesized normal amounts of IgG in tissue culture but failed to secrete the newly synthesized IgG. The B lymphocytes of these patients fail to incorporate [3H]mannose and/or [3H]glucosamine into newly synthesized IgG, whereas such incorporation appears to occur just before IgG secretion in cultures of normal B lymphocytes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=436792Documentos Relacionados
- Immunoglobulin variable heavy chain cDNA sequence from a patient with X-linked agammaglobulinemia.
- HLA-A and -B alleles and haplotypes in 240 index patients with common variable immunodeficiency and selective IgG subclass deficiency in central Alabama
- IgG monoclonal gammopathy in four patients with polymyalgia rheumatica.
- Profile of total IgG, IgG1, IgG2, IgG3 and IgG4 levels in sera of patients with paracoccidioidomycosis: treatment follow-up using Mexo and rPb27 as antigens in an ELISA
- Bone marrow-derived lymphoid cell lines from patients with agammaglobulinemia.
