Family of middle repetitive DNA sequences in the mouse genome with structural features of solitary retroviral long terminal repeats.
AUTOR(ES)
Wirth, T
RESUMO
Screening of a 129/J mouse genomic library under nonstringent hybridization conditions with a xenotropic virus-like long terminal repeat (LTR) probe revealed a family of sequences resembling insertion elements (IS) with structural features of solitary retroviral LTRs; these are called LTR-IS. They are interspersed among variable flanking regions of mouse DNA and lack any viral structural genes. LTR-IS elements start and end with 11-base-pair inverted repeats and contain signals implicated in RNA polymerase II transcriptional regulation: C-C-A-A-T, T-A-T-A-A-A, and A-A-T-A-A-A. The members of the family are homologous, but not identical, approximately equal to 500-base-pair-long elements with 4-base-pair target-site duplications on both sites of the element. There are 500 LTR-IS per mouse haploid genome.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=394035Documentos Relacionados
- A chicken middle-repetitive DNA sequence which shares homology with mammalian ubiquitous repeats.
- Nucleotide sequence analysis of the long terminal repeat of integrated simian sarcoma virus: evolutionary relationship with other mammalian retroviral long terminal repeats.
- Functional RNA polymerase II promoters in solitary retroviral long terminal repeats (LTR-IS elements).
- Nucleotide sequences of the retroviral long terminal repeats and their adjacent regions.
- A family of short, interspersed repeats is associated with tandemly repetitive DNA in the human genome.