FLUOROUS SUPPORTED SYNTHESIS OF PYRAZOLONE DERIVATIVES FROM ALLYLIC ALCOHOLS USING A PALLADIUM-CATALYZED STRATEGY

AUTOR(ES)

Gouault, Nicolas, Cariou, Alexandre, Cupif, Jean-François, Amaral, Patrícia de Aguiar, David, Michèle

FONTE

Quím. Nova

DATA DE PUBLICAÇÃO

2016-08

RESUMO

Ten substituted pyrazolone derivatives were easily synthesized from perfluorinated allylic alcohols, via a straightforward two steps reaction involving a Heck-coupling/isomerization reaction and subsequent condensation of hydrazines. This fluorous supported methodology, that combines a cyclo-release approach and F-SPE purification allows for the obtaining of the final products with a good purity.

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