Folding pathway of a lattice model for proteins
AUTOR(ES)
Pande, Vijay S.
FONTE
The National Academy of Sciences
RESUMO
The folding of a protein-like heteropolymer is studied by using direct simulation of a lattice model that folds rapidly to a well-defined “native” structure. The details of each molecular folding event depend on the random initial conformation as well as the random thermal fluctuations of the polymer. By analyzing the statistical properties of hundreds of folding events, a classical folding “pathway” for such a polymer is found that includes partially folded, on-pathway intermediates that are shown to be metastable equilibrium states of the polymer. These results are discussed in the context of the “classical” and “new” views of folding.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=15453Documentos Relacionados
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