Formation of internucleotide 3'-5' phosphoramidate links by direct coupling of phosphoryl and amino groups.
AUTOR(ES)
Greene, G L
RESUMO
The stepwise synthesis of oligomers derived from 5'-amino-5'-deoxythymidine 3'-phosphate and 5'-amino-5'-deoxy-3'-O-mono-p-methoxytrityl-thymidine is described. The internucleotide phosphoramidate links were formed by condensation of nucleoside 3'-phosphates with aminonucleosides by means of triphenylphosphine and dipridyl disulfide.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=343499Documentos Relacionados
- Inhibition of pancreatic ribonuclease by 2'-5' and 3'-5' oligonucleotides.
- Chemical synthesis of 5'-pyrophosphate and triphosphate derivatives of 3'-5' ApA, ApG, GpA and GpG. CD study of the effect of 5'-phosphate groups on the conformation of 3'-5' GpG.
- The preparation and properties of 4-thiouridine containing 2'-5' and 3'-5' dinucleoside monophosphates.
- 3'-5' proofreading-induced detection of point mutations by PCR using Tli DNA polymerase.
- Cyclic 3'-5' guanosine monophosphate-dependent activity in Leishmania amazonensis