Frameshift mutations at two hotspots in vasopressin transcripts in post-mitotic neurons.
AUTOR(ES)
Evans, D A
RESUMO
Mutations in DNA underlie carcinogenesis, inherited pathology, and aging and are generally thought to be introduced during meiosis and mitosis. Here we report that in post-mitotic neurons specific frameshift mutations occur at high frequency. These mutations were identified in vasopressin transcripts in magnocellular neurons of the homozygous Brattleboro rat and predominantly consist of a GA deletion in GAGAG motifs. Immunocytochemistry provides evidence for similar events in wild-type rats. However, the diseased state of the Brattleboro rat, resulting in a permanent activation of vasopressin neurons, enhanced the mutational rate. These data reveal hitherto unrecognized somatic mutations in nondividing neurons.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=44137Documentos Relacionados
- Notch signaling regulates the differentiation of post-mitotic intestinal epithelial cells
- Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells.
- Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells
- Two types of muscarinic response to acetylcholine in mammalian cortical neurons.
- Neurons with graded response have collective computational properties like those of two-state neurons.