From genetics to pathology: tau and alpha-synuclein assemblies in neurodegenerative diseases.
AUTOR(ES)
Goedert, M
RESUMO
The most common degenerative diseases of the human brain are characterized by the presence of abnormal filamentous inclusions in affected nerve cells and glial cells. These diseases can be grouped into two classes, based on the identity of the major proteinaceous components of the filamentous assemblies. The filaments are made of either the microtubule-associated protein tau or the protein alpha-synuclein. Importantly, the discovery of mutations in the tau gene in familial forms of frontotemporal dementia and of mutations in the alpha-synuclein gene in familial forms of Parkinson's disease has established that dysfunction of tau protein and alpha-synuclein can cause neurodegeneration.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1088427Documentos Relacionados
- Charge neutralization and collapse of the C-terminal tail of alpha-synuclein at low pH
- Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice
- Molecular genetics in neurologic diseases.
- Understanding Pathology: From Disease Mechanisms to Clinical Practice
- Molecular genetics of common diseases.