Fungal Phospholipase Activity and Susceptibility to Lipid Preparations of Amphotericin B
AUTOR(ES)
Gottfredsson, Magnus
FONTE
American Society for Microbiology
RESUMO
It has been postulated that phospholipases of fungal origin can affect in vitro susceptibility testing of amphotericin B lipid complex (ABLC). We used specific phospholipase-deficient mutants of Candida albicans and Cryptococcus neoformans in susceptibility testing and demonstrated that extracellular fungal phospholipase activity does not influence the in vitro susceptibilities of these two fungi to ABLC.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=90814Documentos Relacionados
- Amphotericin B lipid complex therapy of experimental fungal infections in mice.
- Comparative Susceptibility of Candida albicans to Amphotericin B and Amphotericin B Methyl Ester
- Drug susceptibility in emerging fungal infections: tests with fluconazole, itraconazole, and amphotericin B
- Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins
- Dose Range Evaluation of Liposomal Nystatin and Comparisons with Amphotericin B and Amphotericin B Lipid Complex in Temporarily Neutropenic Mice Infected with an Isolate of Aspergillus fumigatus with Reduced Susceptibility to Amphotericin B