Gadolinium inhibits mechanoelectrical transduction in rabbit carotid baroreceptors. Implication of stretch-activated channels.
AUTOR(ES)
Hajduczok, G
RESUMO
Gadolinium (Gd3+) has been shown to prevent mechanoelectrical transduction believed to be mediated through stretch-activated channels. We investigated the possible role of Gd(3+)-sensitive channels in mediating baroreceptor activity in the carotid sinus of rabbits. Baroreceptor activity induced by a ramp increase of carotid sinus pressure was reduced significantly during exposure to Gd3+. The inhibition was dose-related and reversible, and was not associated with alteration of carotid sinus wall mechanics as the pressure-strain relationship was unaffected. Veratrine triggered action potentials from single- and multiple-baroreceptor fibers when their response to pressure was inhibited by Gd3+. This suggests that the effect of Gd3+ on baroreceptors in the isolated carotid sinus was specific to their mechanical activation. The results suggest that stretch-activated ion channels sensitive to Gd3+ may be the mechanoelectrical transducers of rabbit carotid sinus baroreceptors.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=330069Documentos Relacionados
- Characterization of stretch-activated ion channels in Xenopus oocytes.
- Stretch-activated anion currents of rabbit cardiac myocytes.
- Block of stretch-activated atrial natriuretic peptide secretion by gadolinium in isolated rat atrium.
- Identification and Characterization of Stretch-Activated Ion Channels in Pollen Protoplasts1
- Stretch-activated channels in single early distal tubule cells of the frog.