Genes required for Drosophila nervous system development identified by RNA interference
AUTOR(ES)
Ivanov, Andrej I.
FONTE
National Academy of Sciences
RESUMO
RNA interference was used to screen 3,314 Drosophila double-stranded RNAs, corresponding to ≈25% of Drosophila genes, for genes that affect the development of the embryonic nervous system. RNA-interference-mediated gene silencing in Drosophila embryos resulted in loss-of-function mutant phenotypes for 43 genes, which is 1.3% of the genes that were screened. We found 18 genes that were not known previously to affect the development of the nervous system. The functions of some of the genes are unknown. Other genes encode protein kinases, transcription factors, and signaling proteins, as well as proteins with other functions.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=528945Documentos Relacionados
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