Genetic Analysis of Gv1, a Gene Controlling Transcription of Endogenous Murine Polytropic Proviruses

AUTOR(ES)

Oliver, Peter L.

FONTE

American Society for Microbiology

RESUMO

Gv1 is a genetic locus that coordinately regulates the expression of multiple murine leukemia virus-related endogenous proviral sequences. A quantitative nuclease protection assay for typing Gv1 inheritance has been developed. Use of this assay demonstrates that Gv1 controls transcription of polytropic but not of modified polytropic endogenous proviruses. A combination of genetic techniques were used to map Gv1; these analyses demonstrate that Gv1 lies approximately 37 centimorgans from the centromeric end of mouse chromosome 13.

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