Genetic and Molecular Characterization of the Optomotor-Blind Gene Locus in Drosophila Melanogaster

AUTOR(ES)

Pflugfelder, G. O.

RESUMO

The Drosophila gene optomotor-blind (omb) is involved in the development of a set of giant neurons in the optic lobes and possibly other structures in the imaginal brain. Adult flies have discrete defects in optomotor behavior. The gene has previously been mapped in chromomeres 4C5-6, together with three other genes, bifid, Quadroon and lacquered(gls). We have localized the gene in a genomic walk of 340 kb of DNA. By mapping seven chromosome breakpoints with omb phenotype we determined its minimum size to about 80 kb. From this region more than 20 RNAs of different size and temporal expression pattern are transcribed. Three of them (T3, T7 and T7') stem from primary transcripts of 40-80 kb in length. In its distal part the omb gene overlaps in at least 19 kb with four other complementation units, bifid, l(1)bifid, Quadroon and lacquered(gls). The three nonlethals affect the external appearance of the fly and seem to be unrelated to brain development.

Documentos Relacionados

• Gypsy retrotransposon as a tool for the in vivo analysis of the regulatory region of the optomotor-blind gene in Drosophila
• The lethal(1)optomotor-blind gene of Drosophila melanogaster is a major organizer of optic lobe development: isolation and characterization of the gene.
• Molecular organization and expression of the genetic locus glued in Drosophila melanogaster.
• Molecular and Genetic Characterization of the Drosophila Melanogaster 87e Actin Gene Region
• Cloning and molecular characterization of the trithorax locus of Drosophila melanogaster.