Genetic studies of the Fv-1 locus of mice: linkage with Gpd-1 in recombinant inbred lines.

AUTOR(ES)

Taylor, B A

RESUMO

Multiple recombinant inbred lines, derived from crosses between strains permissive to N-tropic murine leukemia viruses (Fv-1n) and strains permissive to B-tropic murine leukemia viruses (Fv-1b), have been characterized as to Fv-1 genotype and other chromosome 4 markers, including the closely linked hexose-6-phosphate dehydrogenase isozyme locus (Gpd-1). Only one recombinant between Fv-1 and Gpd-1 was found among 45 lines tested. On this basis, the distance between Fv-1 and Gpd-1 is estimated to be 0.6 centimorgans. None of the lines was either resistant or susceptible to both N- and B-tropic viruses. Nineteen other inbred strains, previously untested, were characterized as either Fv-1n or Fv-1b.

Documentos Relacionados

• The genetic structure of recombinant inbred mice: high-resolution consensus maps for complex trait analysis
• Genetic evidence for a product of the Fv-1 locus that transfers resistance to mouse leukemia viruses.
• Studies with aphidicolin on the Fv-1 host restriction of Friend murine leukemia virus.
• Effect of the Fv-1 locus on the titration of murine leukemia viruses.
• The Nxsm Recombinant Inbred Strains of Mice: Genetic Profile for 58 Loci Including the Mtv Proviral Loci