Genetic Susceptibility of Mice to Candida albicans Vaginitis Correlates with Host Estrogen Sensitivity

AUTOR(ES)

Clemons, Karl V.

FONTE

American Society for Microbiology

RESUMO

We compared susceptibility to Candida vaginitis in derived murine substrains differing in sensitivity to estrogen (CD-1 and CD10, resistant; CD3 and C57BL/6 responsive), and in F1 crosses. The order of decreasing resistance was CD-1 ≥ CD10 ≥ CD10 × CD3F1 > CD10 × B6F1 > CD3 > C57BL/6 and correlated with estrogen responsiveness in endocrine disruptor assays. Resistance to Candida vaginitis appears additive in CD10 × B6F1 animals and dominant in CD10 × CD3F1 animals.

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