Genomic complexities of murine leukemia and sarcoma, reticuloendotheliosis, and visna viruses.
AUTOR(ES)
Beemon, K L
RESUMO
The genetic complexities of several ribodeoxyviruses were measured by quantitative analysis of unique RNase T1-resistant oligonucleotides from 60-70S viral RNAs. Moloney murine leukemia virus was found to have an RNA complexity of 3.5 x 10(6) daltons, whereas Moloney murine sarcoma virus had a significantly smaller genome size of 2.3 x 10(6). Reticuleondotheliosis and visna virus RNAs had complexities of 3.9 x 10(6), respectively. Analysis of RNase A-resistant oligonucleotides of Rous sarcoma virus RNA gave a complexity of 3.6 x 10(6), similar to that previously obtained with RNase T1-resistant oligonucleotides. Since each of these viruses was found to have a unique sequence genomic complexity near the molecular weight of a single 30-40S viral RNA subunit, it was concluded that ribodeoxyvirus genomes are at least largely polyploid.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=515444Documentos Relacionados
- Glycopeptides of murine leukemia viruses. II. Comparison of xenotropic and dual-tropic viruses.
- Comparison of the genomic organization of Kirsten and Harvey sarcoma viruses.
- Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses.
- Primary structure of p19 species of avian sarcoma and leukemia viruses.
- Hydrodynamic Diameters of Murine Mammary, Rous Sarcoma, and Feline Leukemia RNA Tumor Viruses: Studies by Laser Beat Frequency Light-Scattering Spectroscopy and Electron Microscopy