Genomic localization of hepatitis B virus in a human hepatoma cell line.
AUTOR(ES)
Zerial, M
RESUMO
The integration of hepatitis B viral sequences in the human hepatoma Alexander cell line has been investigated after fractionation of the cell line DNA by centrifugation in a Cs2SO4/BAMD (3,6-(bis-acetato mercurimethyl) dioxane) density gradient. Eight out of nine integrated viral sequences were localized in DNA component H3, which only represents 4% of the human genome and matches the base composition of HBV sequences. These results indicate a targeting and/or a higher stability of the latter in a specific, small compartment of the host genome.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=311865Documentos Relacionados
- Production of infectious duck hepatitis B virus in a human hepatoma cell line.
- In vitro propagation of human hepatitis B virus in a rat hepatoma cell line.
- Production of hepatitis delta virus and suppression of helper hepatitis B virus in a human hepatoma cell line.
- State of hepatitis B viral DNA in a human hepatoma cell line.
- Sequence of hepatitis B virus DNA incorporated into the genome of a human hepatoma cell line.